Irritation of Microbially Produced Volatile Organic Compounds in Mice During
Anne Korpi, PH. LIC., Jukka-Pekka Kasanen, M.Sc., Anna-Liisa Pasanen, Ph.D. Department of Environmental Sciences, Kuopio, Finland; email: firstname.lastname@example.org
Microbially produced volatile organic compounds (MVOCs) are suspected to cause eye, nose and throat irritation in occupants of moldy buildings. The effect of repeated exposures (30 minutes per day during 4 consecutive days) of mice to 3-octanone (3531 mg/m3), 1-octen-3-ol (36 mg/m3), or to a mixture of five MVOCs (58 mg/m3) via inhalation was studied with a standardized method (ASTM E 981-84). With single MVOCs, no changes in the responses between repetitions of exposure were seen, and only a very slight adaptation in the respiratory response was noted along with the repetition of exposure to a mixture of MVOCs. Thus, during a short-term experiment, repeated exposure to MVOCs did not provoke changes in the sensation of irritation nor cause permanent effects on upper respiratory tract.