Subject: Aflatoxin B1 and reproduction  

1: Afr J Reprod Health. 1997 Sep;1(2):85-9.

Aflatoxin B1 and reproduction. II. Gametoxicity in female rats

Ibeh IN, Saxena DK.

Department of Microbiology, Faculty of Science, University of Benin, Nigeria.

It has been reported that aflatoxin B1 impairs the reproductive performance of female animals. The mechanism of action of this toxin on the reproductive system was investigated. Female Druckery Strain rats were administered aflatoxin B1 at doses of 7.5 and 15.0 mg/kg body weight through oral intubation for 21 days. The ovary was examined by counting superovulated oocytes and the follicles in 6 mm thick sections. Estradiol and progesterone blood levels were determined. The body and whoopy organ weights of rats were recorded. There were significant reductions in the number of oocytes and large follicles in a dose dependent response. The blood hormone level and body and whoopy organ weight were significantly disturbed. We propose that aflatoxin B1 is gametotoxic and deranges hormonal balance in affected animals.