Research Article
Long term effect of aflatoxin B1 on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin
Ravi Rastogi, Arvind Kumar Srivastava *, Anil Kumar Rastogi
Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001, India

*Correspondence to Arvind Kumar Srivastava, Biochemistry Division, Central Drug Research Institute, Lucknow 226 001, India

CDRI Communication No. 5992

aflatoxin-B1; picroliv; silymarin; Picrorhiza kurroa
Aflatoxin B1 (AFB1) is a potent hepatotoxic and hepatocarcinogenic mycotoxin. The mechanism of cellular damage caused by AFB1 has not been fully elucidated. Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenesis of many carcinogens. The present investigation aims at assessing the comparative antioxidant effet of picroliv, a standardized iridoid glycoside fraction of Picrorhiza kurroa and silymarin, a well known standard hepatoprotective, on aflatoxin B1 induced lipid-peroxidation in rat liver and kidney. Marked increases in lipid peroxide levels and a concomitant decrease in enzymic antioxidant levels were observed in aflatoxin B1 (2 mg/kg, i.p) -toxicated rats, while drug (picroliv and silymarin both) treatment reversed the condition to near normal levels. The effects of picroliv and silymarin were comparable. Copyright 2001 John Wiley & Sons, Ltd.

Received: 13 January 2000; Accepted: 4 April 2000