|
Research Article
Long term
effect of aflatoxin B1 on lipid peroxidation in rat
liver and kidney: effect of picroliv and silymarin
|
Ravi Rastogi, Arvind Kumar
Srivastava *,
Anil Kumar Rastogi |
Division of Biochemistry,
Central Drug Research Institute, Lucknow-226 001, India
|
*Correspondence
to Arvind Kumar Srivastava, Biochemistry Division, Central Drug
Research Institute, Lucknow 226 001, India
CDRI Communication No. 5992
aflatoxin-B1;
picroliv; silymarin; Picrorhiza kurroa |
Aflatoxin B1 (AFB1)
is a potent hepatotoxic and hepatocarcinogenic mycotoxin. The
mechanism of cellular damage caused by AFB1 has not
been fully elucidated. Lipid peroxidation is one of the main
manifestations of oxidative damage and has been found to play an
important role in the toxicity and carcinogenesis of many
carcinogens. The present investigation aims at assessing the
comparative antioxidant effet of picroliv, a standardized iridoid
glycoside fraction of Picrorhiza kurroa and silymarin, a
well known standard hepatoprotective, on aflatoxin B1
induced lipid-peroxidation in rat liver and kidney. Marked
increases in lipid peroxide levels and a concomitant decrease in
enzymic antioxidant levels were observed in aflatoxin B1
(2 mg/kg, i.p) -toxicated rats, while drug (picroliv and silymarin
both) treatment reversed the condition to near normal levels. The
effects of picroliv and silymarin were comparable. Copyright ©
2001 John Wiley & Sons, Ltd. |
Received: 13 January 2000; Accepted:
4 April 2000
|
|