[Course and therapy of an invasive aspergilloma of the skull base in a non-immunocompromised patient]

[Article translated from German]

Wenzel S, Sagowski C, Kehrl W, Metternich FU.

Klinik und Poliklinik fur Hals-, Nasen- und Ohrenheilkunde des Universitatsklinikum Hamburg-Eppendorf, swenzel@uke.uni-hamburg.de

Fulminant-invasive sinus aspergillosis affects immunocompromised patients and is usually lethal because of intracranial complications. Chronic-invasive and non-invasive types occur in non-immunocompromised patients. In these cases, intracranial extension is possible and life-threatening. The effective management of sinus aspergillosis requires early diagnosis by CT and histological classification, surgery, and if necessary, chemotherapy or steroids in case of allergy. Here we report a successfully treated case in a 29-year-old non-immunocompromised patient with chronic-invasive sinus aspergillosis. He presented a recurrent sphenoid sinus aspergillosis with destruction of the clivus and ophthalmoplegia. Diagnostic and therapeutic procedures are described.

PMID: 15309253 [PubMed - in process]